HLA-DRA (MHC II) Antibody - With BSA and Azide, Clone: [169-1B5.2], Mouse, Monoclonal
Artikelnummer:
ABT-AH11431-U0020
- Bilder (0)
| Artikelname: | HLA-DRA (MHC II) Antibody - With BSA and Azide, Clone: [169-1B5.2], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH11431-U0020 |
| Hersteller Artikelnummer: | AH11431-U0020 |
| Alternativnummer: | ABT-AH11431-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Feline, Human |
| Alternative Synonym: | HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen DRA, HLA-DRA, HLA-DRA1 |
| This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. |
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