Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human TIMP3
Alternative Synonym:
SFD, K222, K222TA2, HSMRK222
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsbys fundus dystrophy.