NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes).
Klonalität:
Monoclonal
Konzentration:
1 mg/ml
Klon-Bezeichnung:
[UIC2]
Isotyp:
Mouse IgG2a kappa
Puffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
