Topoisomerase I, Mitochondrial (TOP1MT) Antibody, IgG2b, Clone: [TOP1MT/488], Mouse, Monoclonal
Artikelnummer:
NBT-116447-MSM1-P1
Hersteller Artikelnummer:
116447-MSM1-P1
Alternativnummer:
NBT-116447-MSM1-P1-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC, IF, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human TOP1MT protein
Alternative Synonym:
DNA topoisomerase I, TOP1MT, Topoisomerase I mitochondrial, Type IB Topoisomerase
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human pancreas stained with Topo I, MT Mouse Monoclonal Antibody (TOP1MT/488).
Formalin-fixed, paraffin-embedded human melanoma stained with Topo I, MT Mouse Monoclonal Antibody (TOP1MT/488).
Immunofluorescent analysis of PFA-fixed MCF-7 cells. Topo I, MT Mouse Monoclonal Antibody (TOP1MT/488) followed by goat anti-mouse IgG-CF488 (green), nuclear counterstain (RedDot).
Flow Cytometric Analysis of PFA-fixed MCF-7 cells. Topo I, MT Mouse Monoclonal Antibody (TOP1MT/488) followed by goat anti-mouse IgG-CF488 (blue), isotype control (red).
SDS-PAGE Analysis Purified Topo I, MT Mouse Monoclonal Antibody (TOP1MT/488). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Jurkat cell lysate using Topo I, MT Mouse Monoclonal Antibody (TOP1MT/488).
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