Recombinant fragment (around aa 247-382) of human ZAP70 protein (exact sequence is proprietary)
Alternative Names:
Selective T cell defect, SRK, STD, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70,TZK, Zeta chain associated protein kinase 70kDa
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-f
Formalin-fixed, paraffin-embedded human lymphoma stained with ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
Formalin-fixed, paraffin-embedded human lymphoma stained with ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
SDS-PAGE Analysis of Purified ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Jurkat cell lysate using ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
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