Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimers disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[DBN-N-03]
Isotype:
Mouse IgG2b
Buffer:
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
