CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[BY55]
Isotype:
Mouse IgM kappa
Buffer:
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Storage:
2°C to 8°C
Target:
CD160
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow cytometry: Recommended dilution: 1-4 µg/ml.
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