purified granules from human YT lymphoma cell line
Perforin is a 70 kDa cytolytic protein with structural and functional similarities to complement component 9 (C9). It is stored in cytoplasmic granules of cytotoxic T cells and NK cells and after its release it forms transmembrane pores in the target cells to kill it. As perforin is a key effector molecule for cell-mediated cytolysis, defects of its gene can cause severe disorders.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[dG9]
Isotype:
Mouse IgG2b kappa
Buffer:
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
