Monoclonal Antibody to CD20 (Clone: ABM46C7) FITC Conjugated
Artikelnummer:
ABI-10-4162-F-25
Hersteller Artikelnummer:
10-4162-F-25
Alternativnummer:
ABI-10-4162-F-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant protein corresponding to extra cellular domain of CD20 was used as the immunogen for this antibody.
Konjugation:
FITC
Alternative Synonym:
MS4A1||CD20
CD20 is clinically validated as an immunotherapy target for B-cell lymphomas and autoimmune diseases. CD20 consists of large, intracellular, amino- and carboxyterminal portions connected by 4 membrane-spanning domains. Its high expression on malignant B cells and its reported lack of shedding from the surfacemake CD20 an ideal target for antibody-mediated killing. Anti-CD20 antibodies are believed to mediate the therapeutic effect by activation of complement-dependent cytotoxicity (CDC) and largely by antibody-dependent cellular cytotoxicity exerted by recruitment of innate immune effector cells expressing the Fcgamma receptor IIIa.
Fig-1: Cell surface flow analysis of hCD20 in PBMC using 0.5 µg/10 6 cells. Green represents isotype control (ABEOMICS), red represents FITC conjugated anti-hCD20 antibody (10-4162F).
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
