A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody.
Alternative Synonym:
BCL6||BCL5||LAZ3||ZBTB27||ZNF51
BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.
Fig-1: Western blot analysis of BCL-6. Anti- BCL-6 antibody (Clone: ABM44G9) was tested at 0.5 µg/ml and 2 µg/ml on (1) recombinant protein and (2) human brain lysates respectively
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