Monoclonal Antibody to Human PD-L1 (Clone: ABM4E54) PE Conjugated
Artikelnummer:
ABI-10-7562-P
Hersteller Artikelnummer:
10-7562-P
Alternativnummer:
ABI-10-7562-P-100TEST
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS
Spezies Reaktivität:
Human
Immunogen:
A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.
Konjugation:
PE
Alternative Synonym:
CD274||B7H1||PDCD1L1||PDCD1LG1||PDL1
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitates apoptosis of activated T cells, and induces T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
Fig-1: Cell Surface FLOW analysis of PD-L1- PE in PHA treated human PBMC using 1 µg of PE conjugated PD-L1 antibody (Clone: ABM4E54). Green represents isotype control (ABEOMICS), red represents anti-PD-L1-PE (10-7562-PE) antibody.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
