Monoclonal Antibody to c-erbB-2/Her2 (Clone: ABM45F5)
Artikelnummer:
ABI-10-7563-25
Hersteller Artikelnummer:
10-7563-25
Alternativnummer:
ABI-10-7563-25-25UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
A partial length protein (amino acids 301-522) was used as the immunogen for this antibody (from extra cellular domain of c-erbB-2).
Alternative Synonym:
ERBB2||HER2||MLN19||NEU||NGL
HER2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12), encoding a type 1 tyrosine kinase growth factor receptor and the role of HER2 in the development of numerous types of human cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity.The high-expression and amplification of C-erbB-2 and its protein products (P185) are found in a wide variety of tumors. HER2 is overexpressed in 10% to 35% of gastric and gastroesophageal junction (GEJ) adenocarcinomas.
