Phospho-SLP-76 (Tyr128) (Clone: 3F8) rabbit mAb PE conjugate, Clone: [SLP76Y128-3F8], Rabbit, Monoclonal
Artikelnummer:
ABI-12-4180
Hersteller Artikelnummer:
12-4180
Alternativnummer:
ABI-12-4180-100TESTS
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FACS
Spezies Reaktivität:
Human, Mouse
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76
Konjugation:
PE
Alternative Synonym:
Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP76, LCP2
SH2 Domain-Containing Leukocyte Protein Of 76 KDa (SLP-76) is an adaptor protein that plays a role in signal transduction in T cells. Studies using a SLP-76-deficient T cell line have demonstrated that SLP-76 is required for optimal phosphorylation and activation of both PLCg1 and the Ras pathway. SLP-76 phosphorylation is mediated by Zap70 upon TCR stimulation. Within an N-terminal acidic region, SLP-76 possesses three tyrosines (Tyr113, 128, and 145), which are phosphorylated upon activation. The sterile alpha-motif (SAM) domain of SLP-76 drives formation of dimers and higher order oligomers. SLP-76 micro-clusters at the immunological synapse enhance signal transduction and T cell activation.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[SLP76Y128-3F8]
Formulierung:
Conjugated
Application Verdünnung:
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
