Phospho-Stat4 (Tyr693) (Clone: F6) rabbit mAb PE conjugate, Clone: [Stat4Y693-F6], Rabbit, Monoclonal
Artikelnummer:
ABI-12-4233-10
Hersteller Artikelnummer:
12-4233-10
Alternativnummer:
ABI-12-4233-10-10TESTS
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FACS
Spezies Reaktivität:
Human, Mouse
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr693 of human phospho Stat4
Konjugation:
PE
Alternative Synonym:
Signal transducer and activator of transcription 4
In response to IL-12 binding, the IL-12 receptor activates the Jak kinases, which phosphorylate tyrosine residues of IL-12RB2. These phosphorylated receptors recruit Stat4 through its SH2 domain, whereupon Stat4 is phosphorylated at Tyr693 in its C-terminal transactivation domain. Phosphorylation promotes Stat4 homodimerization and translocation to the nucleus, where it promotes gene transcription. The N-terminal domain of Stat4 appears to be required for maximal stabilization and for the binding of Stat4 dimers to lower-affinity DNA binding sites. Stat4-deficient mice have demonstrated that this gene is required to both promote Th1 development and inhibit Th2 differentiation due to disabling IL-12 receptor-mediated responses.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[Stat4Y693-F6]
Formulierung:
Conjugated
Application Verdünnung:
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
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