Phospho-mTOR (Ser2448) (Clone: E11) rabbit mAb PE Conjugate, Clone: [mTORS2448-E11], Rabbit, Monoclonal
Artikelnummer:
ABI-12-4296-10
Hersteller Artikelnummer:
12-4296-10
Alternativnummer:
ABI-12-4296-10-10TESTS
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FACS
Spezies Reaktivität:
Human
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser2448 of human phospho mTOR
Konjugation:
PE
Alternative Synonym:
Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, FRAP, FRAP1, FRAP2, RAFT1, RA
mTOR, mammalian target of rapamycin, is a Serine/Threonine protein kinase (1-2) that functions as an amino acid and ATP sensor to balance cell growth and nutrient availability (3-4). When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of 4E-BP1 (5). mTOR plays a key role in homeostasis and cell growth, and phospho mTOR may be abnormally regulated in tumors. mTOR is a potential target for anti-cancer therapy (6).
Klonalität:
Monoclonal
Klon-Bezeichnung:
[mTORS2448-E11]
Application Verdünnung:
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for add
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