Anti-Ross River Virus (Clone: RRV-12), Clone: [RRV-12], Human, Monoclonal
Artikelnummer:
ABI-12-8132
Hersteller Artikelnummer:
12-8132
Alternativnummer:
ABI-12-8132-100UG
Hersteller:
Abeomics
Wirt:
Human
Kategorie:
Sonstiges
Immunogen:
A panel of human mAbs, including clone RRV-12, were sequenced from the peripheral blood mononuclear cells of two donors who were naturally infected with RRV
Alternative Synonym:
RRV
Reactivity Species : Ross River-Virus Expression Host :HEK-293 Endotoxin Level : 1.0 EU/mg as determined by the LAL method Specificity: RRV-12 activity is directed against the E2 protein. Antigen Distribution : RoE2 is expressed on the surface of RRV. Background : Ross River Virus (RRV) is a mosquito-borne, positive sense, single-stranded virus endemic to Australia and Papua New Guinea that belongs to the arthritogenic group of alphaviruses1. The mature glycoprotein is composed of E1 and E2 envelope proteins in a heterodimer, expressed as a trimeric spike on the virus surface . B cells were transformed with Epstein-Barr virus and then screened by direct virus binding ELISA. Hybridoma lines were established and mAbs were purified by single-cell flow cytometric sorting. Clone RRV-12 is of the IgG1 isotype and is capable of binding and incompletely neutralizing prototype strain RRV T48 in a focus reduction neutralization test.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[RRV-12]
Reinheit:
>=95% monomer by analytical SEC
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