Specificity: Clone MARV-72 is a human IgG monoclonal antibody that specifically targets the top portion from the head domain of glycoprotein 1 (GP1) of the Marburg Virus (MARV). Antigen Distribution: MARV initially infects monocytes, macrophages, and dendritic cells, which serve as the initial targets of infection and contribute to the spread of the virus throughout the body. Background: MARV is a highly pathogenic virus that belongs to the Filoviridae family, along with Ebola virus1. It can cause severe hemorrhagic fever in humans, with mortality rates as high as 90%2. MARV is transmitted to humans through contact with infected animals, such as fruit bats or monkeys, or direct contact with the bodily fluids of infected individuals3. There are currently no approved vaccines or specific treatments for MARV infection. Research has focused on understanding the viruss replication, immune evasion mechanisms, and developing potential vaccines and therapeutics. Animal models, such as nonhuman primates and guinea pigs, have been used to study the virus and evaluate potential interventions.? Studies on MARVs envelope GP have shown that the virus can evade antibody-mediated immune pressure through mutations in the furin-cleavage site and deletion of the mucin-like region, demonstrating the GPs structural flexibility and variability4. These findings contribute to our understanding of MARVs life cycle, immune evasion mechanisms, and potential therapeutic approaches. Clone MARV-72 (also known as MR72) is recognized for its wide-ranging reactivity against filoviruses, such as Ebola and Marburg viruses. It is noteworthy for being one of the rare antibodies capable of attaching to GPs of both types of viruses, making it highly sought after for therapeutic applications. MARV-72 has demonstrated its efficacy in neutralizing these viruses and offering protection in non-human primate models5.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[MARV-72]
Reinheit:
Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Target-Kategorie:
Marburg
Application Verdünnung:
ELISA, EM, N
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