Anti-West Nile Virus (Clone: WNV-99)-Purified No Carrier Protein, Clone: [WNV-99], Monoclonal
Artikelnummer:
ABI-12-8274
Hersteller Artikelnummer:
12-8274
Alternativnummer:
ABI-12-8274-250UG
Hersteller:
Abeomics
Kategorie:
Antikörper
Applikation:
ELISA
Specificity: WNV-99 activity is directed against the wing, flexible loop of NS1. During the screening phase and post characterization clone WNV-99 was found to bind to solid-phase recombinant WNV NS1 protein and to NS1 expressed on the surface of intact WNV-infected Vero cells. Plus, also engaged the hexameric form of NS1. WNV-99 was cross-reactive against Japanese Encephalitis Virus and Tick-borne Encephalitis Virus in a direct ELISA using recombinant NS1 proteins. Background: West Nile Virus (WNV) is a mosquito-borne, enveloped, positive-stranded RNA flavivirus1. Flavivirus nonstructural protein NS1 has been proposed as an antibody target to avoid antibody-dependent enhancement2. NS1 is a 46-55 kDa glycoprotein that is expressed as a dimer on the cell surface and as a soluble hexamer in the extracellular space and in circulation during infection. WNV NS1 dimer consists of a ?-roll, wing, and ?-ladder.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[WNV-99]
Reinheit:
Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Target-Kategorie:
West Nile virus
Application Verdünnung:
ELISA FC
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