The poly-Glycine-Serine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect antibody fragments (scFvs) and fusion proteins . The linker itself consists of a core pentapeptide sequence, Gly-Gly-Gly-Gly-Ser, that is repeated and commonly found as either a 15-mer (G4S)3 or 20-mer (G4S)4 within scFv-based CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[12H7]
Puffer:
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
Reinheit:
Purified from cell culture supernatant by affinity chromatography
Target-Kategorie:
G4S linker
Antibody Type:
Recombinant Antibody
Application Verdünnung:
ELISA 1/5000-10000
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