The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[DMC388]
Reinheit:
Purified from cell culture supernatant by affinity chromatography
Target-Kategorie:
EDA
Antibody Type:
Recombinant Antibody
Application Verdünnung:
FACS 1/100
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