This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Klonalität:
Monoclonal
Klon-Bezeichnung:
[DM157]
Reinheit:
Purified from cell culture supernatant by affinity chromatography
Target-Kategorie:
MICA
Antibody Type:
Recombinant Antibody
Application Verdünnung:
ELISA 1/5000-10000,FACS 1/100
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