The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[DM159]
Reinheit:
Purified from cell culture supernatant by affinity chromatography
Target-Kategorie:
NTB-A
Antibody Type:
Recombinant Antibody
Application Verdünnung:
ELISA 1/5000-10000,FACS 1/100
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