Human ACKR2 Full Length Protein (VLP), Unconjugated
Artikelnummer:
ABS-AC2-H52P3-500UG
Hersteller Artikelnummer:
AC2-H52P3-500ug
Alternativnummer:
ABS-AC2-H52P3-500UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Atypical chemokine receptor that controls chemokine levels and localization via highaffinity chemokine binding that is uncoupled from classic liganddriven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokinescavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP1, SCY3/MIP1alpha, SCYA5/RANTES and SCYA7/MCP3. Upon active ligand stimulation, activates a betaarrestin 1 (ARRB1)dependent, G proteinindependent signaling pathway that results in the phosphorylation of the actinbinding protein cofilin (CFL1) through a RAC1PAK1LIMK1 signaling pathway. Activation of this pathway results in upregulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. - Proteine/Peptide
