Unconjugated Human Nectin-4 Protein, His,Avitag(TM) (MALS verified)
Artikelnummer:
ABS-NE4-H52E3-100UG
Hersteller Artikelnummer:
NE4-H52E3-100ug
Alternativnummer:
ABS-NE4-H52E3-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Nectin4(Nectin cell adhesion molecule 4) is a Nectin and nectinlike family of cell adhesion molecules. It is found in high levels in normal embryonic and fetal tissues, but decreases after adulthood and is limited in distribution in healthy tissues. Nectin4 is overexpressed in a variety of tumor cells and promotes tumor cell growth and proliferation. Solid tumors with high expression of Nectin4 include bladder cancer, pancreatic cancer, triple negative breast cancer, nonsmall cell lung cancer, stomach cancer, esophageal cancer, ovarian cancer and many other cancers. Studies have found that Nectin4 promotes tumor cell proliferation, differentiation, migration and invasion by activating the PI3K/Akt pathway, and is believed to play an important role in the occurrence and metastasis of cancer. It is based on these research backgrounds that drug research targeting this target has emerged. - Proteine/Peptide
