INPP5D Antibody - C-terminal region
Artikelnummer:
ASB-ARP61033_P050
- Bilder (3)
| Artikelname: | INPP5D Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP61033_P050 |
| Hersteller Artikelnummer: | ARP61033_P050 |
| Alternativnummer: | ASB-ARP61033_P050-25UL,ASB-ARP61033_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Alternative Synonym: | SHIP, SHIP1, SHIP-1, hp51CN, SIP-145, p150Ship |
| This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5 phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
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WB Suggested Anti-INPP5D Antibody Titration: 1.0 ug/ml Positive Control: THP-1 Whole Cell |
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25 ug of the indicated Mouse whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. |
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INPP5D antibody - C-terminal region (ARP61033_P050) in Human THP-1 using Western Blot |
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