WISP1 Antibody - middle region
Artikelnummer:
ASB-ARP63882_P050
- Bilder (3)
| Artikelname: | WISP1 Antibody - middle region |
| Artikelnummer: | ASB-ARP63882_P050 |
| Hersteller Artikelnummer: | ARP63882_P050 |
| Alternativnummer: | ASB-ARP63882_P050-25UL,ASB-ARP63882_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Human, Porcine |
| Alternative Synonym: | WISP1, WISP1c, WISP1i, WISP1tc, WISP1-OT1, WISP1-UT1 |
| This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. |
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WB Suggested Anti-WISP1 Antibody Titration: 1.0 ug/ml Positive Control: 721_B Whole CellWISP1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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Host: Rabbit Target Name: WISP1 Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml |
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WISP1 antibody - middle region (ARP63882_P050) in Human 721_B using Western Blot |
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