KIR2DL5B Antibody - C-terminal region
Artikelnummer:
ASB-ARP65908_P050
- Bilder (3)
| Artikelname: | KIR2DL5B Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP65908_P050 |
| Hersteller Artikelnummer: | ARP65908_P050 |
| Alternativnummer: | ASB-ARP65908_P050-25UL,ASB-ARP65908_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human, Porcine |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C-terminal region of Human KIR2DL5B |
| Alternative Synonym: | KIR2DL5, KIR2DLX, KIR2DL5.2 |
| Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response. |
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Sample Type: Lane 1: FLAG IPd FLAG-KIR2DL4 transfected NK92 cells Lane 2: FLAG IPd FLAG-KIR2DL5 transfected NK92 cells Primary Antibody Dilution : 1:500 Secondary Antibody:Anti-rabbit-HRP Secondary Antibody Dilution:1:10,000 Submitted by:Kerry S. Campbell, Institute for Cancer Research. |
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WB Suggested Anti-KIR2DL5B Antibody Titration: 1.0 ug/ml Positive Control: Fetal kidney |
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KIR2DL5B Antibody - C-terminal region (ARP65908_P050) in Human Fetal Kidney using Western Blot |
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