KLH conjugated synthetic peptide derived from human Smad2
Konjugation:
Unconjugated
Alternative Synonym:
hMAD-2,hSMAD2,JV18,JV18-1,MAD homolog 2,MADH2,MADR2,Mad-related protein 2,mother against DPP homolog 2,mothers against decapentaplegic homolog 2,Sma- and Mad-related protein 2,SMAD family member 2,SMAD, mothers against DPP homolog 2.
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
