Bovine, Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human ADAMTS5
Konjugation:
Unconjugated
Alternative Synonym:
a disintegrin and metalloproteinase with thrombospondin motifs 11,A disintegrin and metalloproteinase with thrombospondin motifs 5,a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2),ADAM-TS 11,ADAM-TS 5,ADAMTS11,ADAMTS-11,ADAMTS-5,ADAM-TS5,ADMP-2,aggrecanase-2.
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
