Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA)
Konjugation:
Unconjugated
Alternative Synonym:
ACPHD,DnaJ (Hsp40) homolog, subfamily C, member 3,dnaJ homolog subfamily C member 3,endoplasmic reticulum DNA J domain-containing protein 6,ERdj6,ER-resident protein ERdj6,HP58,interferon-induced, double-stranded RNA-activated protein kinase inhibitor,P58,p58(IPK),P58IPK,PRKRI,protein kinase inhibitor of 58 kDa,protein kinase inhibitor p58,protein-kinase, interferon-inducible double stranded RNA dependent inhibitor.
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at Ser-52 and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
