MSN-125 is a cell-permeable small molecule inhibitor of Bax/Bak oligomerization, thereby blocking mitochondrial outer membrane permeabilization (MOMP) and apoptosis. With an IC50 of 4 µM for MOMP inhibition, it has demonstrated protective effects against apoptotic cell death in HCT-116 cells, BMK cells, and primary cortical neurons, including in models of glutamate excitotoxicity.
Molekulargewicht:
688.61
CAS Nummer:
[1592908-16-1]
Formel:
C36H38BrN3O6
Target-Kategorie:
Bcl-2 Family,Apoptosis,Akt
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