SEL-24-B489, SEL24-B489, SEL24-B-489, SEL 24-B489, SEL24 B489, SEL24-B 489, SEL24B489, MEN1703, MEN 1703
Dapolsertib (SEL24-B489) is an orally active, dual inhibitor of PIM kinases and FLT3-ITD. It reduces substrate phosphorylation and triggers apoptosis in leukemia cells in a dose-dependent manner. This compound is utilized in oncology research, showing activity in both cellular assays and in vivo models of hematological malignancies.
