Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein,Membrane component chromosome 17 surface marker 2,Neighbor of BRCA1 gene 1 protein,Protein 1A1-3B)
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],
Immunohistochemical analysis of paraffin-embedded human small intestinal carcinoma tissue. 1,primary Antibody was diluted at 1:200(4 overnight). 2, Sodium citrate pH 6.0 was used for antigen retrieval(>98C,20min). 3,Secondary antibody was diluted at 1:200
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