Synthesized peptide derived from the Internal region of human Caspase-10.
Alternative Synonym:
CASP10, MCH4, Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Western Blot analysis of extracts from Jurkat, K562 cells, using Caspase-10 Polyclonal Antibody. Secondary antibody(catalog:RS0002) was diluted at 1:20000
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