The antiserum was produced against synthesized peptide derived from human MARCH4. AA range:301-350
Alternative Synonym:
MARCH4, KIAA1399, RNF174, E3 ubiquitin-protein ligase MARCH4, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010],
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MARCH4 Antibody. The picture on the right is blocked with the synthesized peptide.
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