CXCR4 (8E12) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE09561
Produktübersicht
Artikelname:
CXCR4 (8E12) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE09561
Hersteller Artikelnummer:
AMRe09561
Alternativnummer:
EKL-AMRE09561-50UL, EKL-AMRE09561-100UL, EKL-AMRE09561-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
CD184 , CXCR4, C-X-C chemokine receptor type 4, FB22, Fusin, HM89, LCR1, LESTR, NPYRL, SDF-1 receptor, Stromal cell- derived factor 1 receptor,
Produktbeschreibung
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin, leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed: 28978524, PubMed: 18799424, PubMed: 24912431). Involved in the AKT signaling cascade (PubMed: 24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed: 28978524). Acts as a receptor for extracellular ubiquitin, leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed: 20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed: 11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
40kDa
NCBI:
7852
UniProt:
P61073
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
CXCR4
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:20-1:500,ICC/IF 1:20-1:100
