EGFR(L858R mutation) (8P17) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE10344
Produktübersicht
Artikelname:
EGFR(L858R mutation) (8P17) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE10344
Hersteller Artikelnummer:
AMRe10344
Alternativnummer:
EKL-AMRE10344-50UL, EKL-AMRE10344-100UL, EKL-AMRE10344-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IHC, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
kinase EGFR, ERBB1, Epidermal growth factor receptor precursor,
Produktbeschreibung
EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed: 10805725, PubMed: 27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF (PubMed: 2790960, PubMed: 7679104, PubMed: 8144591, PubMed: 9419975, PubMed: 15611079, PubMed: 12297049, PubMed: 27153536, PubMed: 20837704, PubMed: 17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed: 27153536). May also activate the NF-kappa-B signaling cascade (PubMed: 11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed: 11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed: 11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed: 20462955). Plays a role in enhancing learning and memory performance (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
134kDa
NCBI:
1956
UniProt:
P00533
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
EGFR
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:100-1:200
