Egr1 (6T16) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE10345
Artikelname: Egr1 (6T16) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE10345
Hersteller Artikelnummer: AMRe10345
Alternativnummer: EKL-AMRE10345-50UL, EKL-AMRE10345-100UL, EKL-AMRE10345-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: ICC, IHC, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24, ZIF-268, EGR1,
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia, regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core- clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).
Klonalität: Monoclonal
Molekulargewicht: 58kDa
NCBI: 1958
UniProt: P18146
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: EGR1
Application Verdünnung: WB 1:2000-1:20000,IHC 1:100-1:200,ICC/IF 1:100-1:200



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