CD4 antibody [RM4-5] (PE), IgG2a, Rat, Monoclonal
Artikelnummer:
GTX43087
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| Artikelname: | CD4 antibody [RM4-5] (PE), IgG2a, Rat, Monoclonal |
| Artikelnummer: | GTX43087 |
| Hersteller Artikelnummer: | GTX43087 |
| Alternativnummer: | GTX43087-100 |
| Hersteller: | GeneTex |
| Wirt: | Rat |
| Kategorie: | Antikörper |
| Applikation: | FC |
| Spezies Reaktivität: | Mouse |
| Immunogen: | BALB/c mouse thymocytes |
| Konjugation: | PE |
| Alternative Synonym: | CD4 antigen , L3T4 , Ly-4 |
| The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. |
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