VU0453379 is a blood-brain barrier permeable GLP-1R positive allosteric modulator (PAM) with an EC50 value of 1.3 µM. VU0453379 potentiates the actions of endogenous GLP-1 and synthetic peptide agonists, and promotes GLP-1 receptor internalization. VU0453379 stimulates insulin secretion from primary mouse islets. VU0453379 enhances the function of endogenous GLP-1R and reverses catalepsy in animal models. VU0453379 is useful for research on Parkinsons disease and type 2 diabetes[1].
Molekulargewicht:
434.57
Reinheit:
98
CAS Nummer:
[1638646-27-1]
Formel:
C26H34N4O2
Target-Kategorie:
GCGR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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