Alloxan is a 26S and 20S proteasome (proteasome) inhibitor and diabetes inducer. Alloxan directly inhibits the chymotrypsin-like and trypsin-like peptidase activities of purified proteasomes. Alloxan induces the accumulation of ubiquitinated proteins by impairing proteasome function. Alloxan is taken up by pancreatic beta cells, increases ROS levels, triggers necrosis, reduces insulin production and induces beta cell death. Alloxan induces vertebral tissue damage, chondrocyte disorder and growth retardation in rat offspring. Alloxan can be used in research related to type 1 diabetes and diabetes[1][2][3].
Molekulargewicht:
142.07
CAS Nummer:
[50-71-5]
Formel:
C4H2N2O4
Target-Kategorie:
Proteasome,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Natural Products
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