9-PAHSA-d4 is the deuterium labeled 9-PAHSA. 9-PAHSA is an orally active endogenous GPR120 agonist (EC50=18 µM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-kappaB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease[1][2][3][4].
Molekulargewicht:
542.91
CAS Nummer:
[2704278-85-1]
Formel:
C34H62D4O4
Target-Kategorie:
CGRP Receptor,Isotope-Labeled Compounds,NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Isotope-Labeled Compounds
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