Succinyl phosphonate, CAS [[26647-82-5]] Preis auf Anfrage
Artikelnummer:
MCE-HY-12688
Hersteller Artikelnummer:
HY-12688
Alternativnummer:
MCE-HY-12688-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Succinyl phosphonate is a alpha-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the alpha-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the alpha-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by beta-amyloid (Amyloid-beta), modulates cognitive function, and prevents beta-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimers disease, aging-related neuroinflammation, and Parkinsons disease[1][2][3][4].
Molekulargewicht:
182.07
Reinheit:
98
CAS Nummer:
[26647-82-5]
Formel:
C4H7O6P
Target-Kategorie:
Amyloid-beta,Mitochondrial Metabolism,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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