E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 µg/ml. E7820 modulates alpha-1, alpha-2, alpha-3, and alpha-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML)[1][2][3].
Molekulargewicht:
336.37
Reinheit:
99.26
CAS Nummer:
[289483-69-8]
Formel:
C17H12N4O2S
Target-Kategorie:
Integrin,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
