DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kalpha, with a Kd of 0.76 µM for p110alpha. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110alpha by nearly three orders of magnitude (KD = 0.017 µM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research[1].
Molekulargewicht:
581.66
Reinheit:
98.24
CAS Nummer:
[2253733-45-6]
Formel:
C29H32FN5O5S
Target-Kategorie:
GLUT,Molecular Glues,PI3K,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
