This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. OOKsp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis CDH16 Recombinant Rabbit Monoclonal Antibody (CDH16/9611R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Human kidney and Rat Kidney tissue lysates using Ksp-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/9611R).
Western Blot Analysis of human kidney tissue lysate using Ksp-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/9611R ).
Western Blot Analysis of Human kidney, Mouse Kidney and Rat Kidney tissue lysates using Ksp-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/9611R).
Formalin-fixed, paraffin-embedded human breast cancer stained with CDH16 Recombinant Rabbit Monoclonal Antibody (CDH16/9611R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
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