Recombinant fragment (around aa200-300) of human OLIG2 protein (exact sequence is proprietary)
Alternative Synonym:
Basic helix loop helix protein class B1 (bHLHB1), basic helix-loop-helix protein 19 (bHLHe19), OLIG2, Oligodendrocyte lineage transcription factor 2, Oligodendrocyte specific bHLH transcription factor 2, Oligodendrocyte transcription factor 2, Protein kinase C-binding protein 2 (PRKCBP2), RACK17
Olig2, a basic helix loop helix transcription factor, is involved in oligo-dendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas. Although more than half of glioblastomas are positive for Olig2, expression is very weak in terms of both percentage of labeled cells and intensity. No Olig2 expression has been found in the non-glial tumors including neuroepithelial tumors, ependymomas, sub-ependymomas, medulloblastomas, and non-neuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid/rhabdoid tumor, and haemangioblastomas. Compared to the strong staining seen in glioma samples, a weak expression is observed in non-tumoral brain tissue.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human cerebrum stained with OLIG2 Recombinant Rabbit Monoclonal Antibody (OLIG2/6695R).
Formalin-fixed, paraffin-embedded human oligodendroglioma stained with OLIG2 Recombinant Rabbit Monoclonal Antibody (OLIG2/6695R).
Formalin-fixed, paraffin-embedded human cerebellum stained with OLIG2 Recombinant Rabbit Monoclonal Antibody (OLIG2/6695R).
IHC analysis of formalin-fixed, paraffin-embedded human brain. Stained with OLIG2/6695R at 2ug/ml in PBS for 30min RT. Inset: PBS instead of primary, secondary antibody negative control.
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