Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human Tonsil stained with Beta-Catenin Mouse Monoclonal Antibody (15B8).
Confocal immunofluorescence image of HeLa cells using Beta-Catenin Mouse Monoclonal Antibody (15B8) labeled is Green (CF488) and Reddot is used to label the nuclei Red.
Western Blot Analysis of HeLa cell lysate using Beta-Catenin Mouse Monoclonal Antibody (15B8).
SDS-PAGE Analysis of Purified Beta-Catenin Mouse Monoclonal Antibody (15B8). Confirmation of Purity and Integrity of Antibody.
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