Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)
Alternative Synonym:
CD105, END, Endoglin, Eng, HHT1, S-endoglin
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
ELISA (For coating, order antibody without BSA), Functional Assays (order antibody without BSA and azide), Flow Cytometry (1-2ug/million cells), Immunofluorescence (2-4ug/ml) Optimal dilution for a specific application should be determined.
Flow Cytometric Analysis of trypsinized PFA-fixed HeLa cells. Endoglin / CD105 Mouse Monoclonal A
Immunofluorescent staining of PFA-fixed HeLa cells with Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621) followed by goat anti-mouse IgG-CF488 (green).
Flow Cytometric Analysis of trypsinized PFA-fixed HeLa cells. Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621) followed by goat anti-mouse IgG-CF488 (Blue), Isotype control (Red).
SDS-PAGE Analysis of Purified Endoglin / CD105 Mouse Monoclonal Antibody (ENG/1621). Confirmation of Integrity and Purity of Antibody.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
