Recombinant fragment (around aa 200-373) of human GLUL protein (exact sequence is proprietary)
Alternative Synonym:
cell proliferation-inducing protein 59, GLUL, Glutamate ammonia ligase, GS, PIG43, PIG59, Glutamate decarboxylase, glutamine synthase, Glutamine synthetase, glutamine synthetase I, Proliferation inducing protein 43, GLNA, GLNS
Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified GLULRecombinant Rabbit Monoclonal Antibody (GLUL/8996R). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of Y79 cell lysate using Glutamine Synthetase Recombinant Rabbit Monoclonal Antibody (GLUL/8996R).
Western Blot analysis of Human Brain, Mouse Brain, Rat Brain, Hamster Brain, Guinea pig Brain, Rabbit Brain, Human Liver, Mouse Liver, Rat Liver, Hamster Liver, Guinea pig Liver, and Rabbit Liver tissue lysates using GLUL Recombinant Rabbit Monoclonal Antibody (GLUL/8996R).
Western Blot validation of anti-GLUL antibody. GLUL protein expression was compared in wild-type (WT) and GLUL shRNA Knockdown (KD) HeLa cells (30ug of total protein). Loading control is shown below.
